Splenomegaly – Definition, Causes, and Treatment.


An enlarged spleen, known formally as splenomegaly, is a medical condition in which a person or animal’s spleen increases in size due to some sort of inflammation or other problem. The swelling doesn’t usually cause any immediate symptoms or pain, and as such people aren’t usually aware of what’s going on. If left untreated it can be very dangerous, though. Most enlargements are a consequence or side effect of some larger, often more serious condition, commonly infection, anemia, or blood cancer. In some of these cases, the spleen acts as a sort of diagnostic marker that can prompt early treatment and, in many cases, a better outcome. There isn’t usually a specific course of treatment to reduce swelling of this organ on a universal level.

Types of Splenomegaly

Depending on the reasons for this pathological condition, its treatment may be different. It should be specially noted that today very often patients speak of a diagnosis such as “splenomegaly of the liver”. Although this term is not entirely correct, in reality, an increase in the spleen is often accompanied by an increase in other internal organs. Such a picture can significantly worsen a patient’s condition and treatment.

Moderate splenomegaly – It is an increase in the spleen, which arose as a result of some pathological phenomena from the side.

Hepatomegaly is a kind of enlargement of the liver, which is combined with an increase in the above-mentioned organ.

Hepatolienal syndrome is a simultaneous increase in both the spleen and the liver.

Risk factors

The risk factors associated with Splenomegaly include:

  • Individuals affected with sickle cell and hemolytic anemia, especially prevalent in an African-American population
  • Individuals affected with Niemann Pick disease and Gaucher disease, especially prevalent in people of Ashkenazi-Jewish descent
  • Children and young adults affected with severe infections, such as mononucleosis
  • Residing in malaria-endemic regions; traveling to areas where malaria is widespread
  • Those with certain chronic conditions, such as rheumatoid arthritis or lupus, are more susceptible to Enlarged Spleen

Causes of Splenomegaly

There are many causes of this pathological condition. They are diverse and often vary from malignant tumors (cancer), overloads (or a strong increase in blood flow), infections and infiltration of the body by other diseases before inflammatory diseases and ailments of blood cells.

Consider the most common causes of an enlarged spleen, which include factors such as:

  • Blood cancer (eg, leukemia, lymphoma or myelofibrosis);
  • Diseases of blood cells (eg, spherocytosis, thalassemia or sickle-cell anemia);
  • Liver disease (eg, chronic hepatitis C, cirrhosis due to chronic hepatitis B, prolonged use of alcoholic beverages and fatty liver disease);
  • Inflammatory diseases (rheumatoid arthritis and lupus erythematosus);
  • Gaucher’s disease (or ailment of lipid metabolism);
  • Abnormal blood flow and blockage of blood vessels, veins (eg, spleen vein thrombosis, congestive heart failure, and portal vein blockage);
  • Thrombocytopenic idiopathic purpura;
  • Various infections (bacterial endocarditis, mononucleosis, AIDS, malaria, Leishmania, mycobacteria, etc.).


An enlarged spleen may cause:

  • No symptoms in some cases
  • Pain or fullness in the left upper abdomen that may spread to the left shoulder
  • Feeling full without eating or after eating only a small amount from the enlarged spleen pressing on your stomach
  • Anemia
  • Fatigue
  • Frequent infections
  • Easy bleeding

Symptoms of spleen

Complications of Splenomegaly

Potential complications of an enlarged spleen are:

Infection: An enlarged spleen can reduce the number of healthy red blood cells, platelets and white cells in your bloodstream, leading to more frequent infections. Anemia and increased bleeding also are possible.

Ruptured spleen: Even healthy spleens are soft and easily damaged, especially in car crashes. The possibility of rupture is much greater when your spleen is enlarged. A ruptured spleen can cause life-threatening bleeding into your abdominal cavity.

Diagnosis and test

Diagnosing splenomegaly involves a number of tests, including:

  • Physical examination
  • Ultrasound or abdominal x-ray
  • Computed tomography (CT) scan
  • Blood tests, to check for underlying disorders.

Treatment and medications

The treatment methods for Splenomegaly may involve the following:

  • In cases where the individual has an Enlarged Spleen without symptoms, a healthcare professional may opt to wait several months, before deciding on a course of action
  • Surgical removal of the spleen, through a splenectomy, in very serious and critical cases
  • Once a decision to remove the spleen is made, the individual is advised to take certain vaccinations, both before and after the surgery, to protect him/her from infections.

The recommended vaccinations may include:

  • Pneumococcal vaccine
  • Meningococcal vaccine
  • Haemophilus influenzae type B vaccine
  • It is also advised that the individual get a pneumococcal vaccine, once every 5 years, following the removal of the spleen
  • Antibiotics, such as penicillin, may be prescribed to combat infections post-surgery
  • Treatment of the underlying condition depending on the cause

Prevention for Splenomegaly

  • Prevention of splenomegaly in itself may be meaningless. Some of the medical causes of splenomegaly, however, may be preventable, such as cessation of alcohol abuse to prevent liver cirrhosis, or prophylaxis against malaria when planning a trip to an endemic area.
  • Preventive measures against a possible rupture of the spleen are noteworthy. Avoiding contact sports and wearing seatbelts are important measures to take for the prevention of splenic rupture.
  • Proper vaccination in patients with splenectomy is also of great significance as noted earlier.

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  1. Thanks I have learnt something new

  2. Pretty Victoria Rose

    please am having stomach pain

  3. thank you for the all inclusive write up.

  4. thank you so much for give me best information about splenomegly

  5. Thank you so much for the health information keep it up with some more am being helped as a medical student in my studyings.

  6. Fedinandi F. Kidaboma

    thank you

  7. Thank you so much but I need informations on heart cancer and its treatment or cure.
    Also I need informations on how to eliminate sickle cells from the blood if that’s possible.

  8. Thank you so much

  9. can you give us about penile facture treatment or details

    • Penile fractures usually require surgery. The surgeon will use stitches to close the tear in the tunica albuginea and corpus cavernosum. The main goals of treatment are to restore or maintain your ability to have erections and preserve urinary function.

      We will be updating a complete post on this topic. Stay tuned.

  10. I really appreciate your write up Thanks

  11. Thank you I have learn more

  12. I have an chronic peptic ulcers more than three years now and i been taking ulcers medicine and no reaction. So how can I get some from the expect doctors?

  13. I have never been associated with being sick and expenditures on different types of medication. until after an accident on the 9th of May 2013, in early 2014 I felt that my whole body wasn’t normal and I consulted a doctor who after checking me said that am alright and that he couldn’t find anything wrong with me. I came back the upper week to let him know that am not alright, the doctor then refered me for to a firm to run a complete test and it was stated that am healthy,

  14. All the test proved negative and I kept on complaining that am not okay, then the doc sent me for X ray and it was said that I had odema of the heart, as a result of enlarge heart. I wasn’t able to walk a distance or tire my shoe lace. I have done everything. Please I need advice on this issue , to know if it’s spleen or the heart enlargement. Thanks.

  15. thank you very much

  16. thanks very much
    its really helpful

  17. Can 30 cm of enlargement of the spleen be safe
    Thanks for your information on spleen I’m a Vietnam vet some say Agent Orange from blue water Navy 1964-1968.

  18. Splenomegaly can cure by using antibiotics?

  19. what causes stomach pain in babies

  20. if your spleen is removed, can you continue alcohol intake or you should quit completely?

  21. Matin Mugyabuso Modest PCB Student.

    Smart, I have liked the precautions, seat belts are usually ignored irrespective their life rescue.

  22. it’s helpful, but i would like to know other option of handling rupture spleen.

    • Repairing the spleen. Your surgeon might be able to use stitches or other techniques to repair the rupture.
      Removing the spleen (splenectomy). If it’s necessary to remove your spleen.
      Removing part of the spleen.

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