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Hemangioma- Overview, Complications, and Treatment

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Definition

Hemangioma is a type of benign (non-cancerous) tumor in infants. This abnormal cluster of small blood vessels appears on or under the skin, typically within one to three weeks after birth. Often, there is no mark or only a faint birthmark on the skin that brightens in color and increases in size over the baby’s first 2-4 months of life (proliferative phase). The area then stabilizes in size and color and then starts to fade and shrink (involution phase). Most hemangiomas are gone by 3 to 5 years of age. Some may cause residual areas of extra skin or small blood vessels called telangiectasias.

The vessel grouping that causes hemangioma

Most infantile hemangiomas cause no complications and go away without treatment. Between 4 to 10 percent of Caucasian infants are born with at least one hemangioma and they are three to five-time more common in females (especially fair-skinned ones) than males. Premature infants are more likely to have a hemangioma, and they occur more frequently in Caucasian infants than Asian infants and are rare in African-Americans

Hemangioma on the skin surface

Types of Hemangioma

Hemangiomas may occur anywhere on the body. Some children may have more than one. There are three main types:

Superficial (on the surface of the skin): These look flat at first, and then become bright red with a raised, uneven surface.

Deep (under the skin):  These appear as a bluish-purple swelling with a smooth surface.

Mixed:  These hemangiomas have both superficial and deep components.

Hemangioma causes

Experts don’t know why these benign tumors form. However, they’re more common in:

Historically, infantile hemangiomas were thought to be more common in females, but this is not always observed. In some cases, hemangiomas run in families. They can also appear spontaneously, so there may be a genetic component to the condition.

There’s no way to prevent hemangiomas of the skin because their exact cause is unknown.

Hemangioma risk factors

Ulceration, Infections, and Bleeding

Ulceration or the formation of a sore is the most common complication of IH. It occurs in up to 15% of cases usually 2 to 3 months after birth, but may also be found in newborn babies. Ulceration is linked to harmful effects on the body and health. It is typically seen on the face and in the area around the anus and genital organs. Ulcerations can be very painful, leave scars upon healing, and even result in disfigurement.

The first signs of ulceration include blackish spots on red patches of skin. Pain can make it difficult to treat the wound. Ulceration can also lead to infection and bleeding which, left untreated, can cause severe anemia and the need for transfusion. Heavy bleeding does not happen often and is rarely life-threatening.

Breathing

While the blocking off the airway is a rare complication of hemangiomas, IH of the upper airways can affect breathing. Such hemangiomas are usually discovered during a routine medical exam of the bronchial tubes. Lesions on the upper lip hardly ever obstruct both nasal passages, but can still be a problem for infants who need to breathe through their nose.

Facial

Frequent complications of ulceration are scarring and disfigurement of the face. ‘Pendulum’ IH can appear on the nose, eyelids, and lips. There is a risk for permanent, significant defects, especially with hemangiomas on the tip of the nose, lips, and ears. These hemangiomas often require more aggressive treatment. Hemangiomas that deform the face can cause emotional pain for parents and children as they get older and begin to socialize.

Vision

A small hemangioma on the upper eyelid can put pressure on the retina, cornea, or optic nerve, and permanently harm a child’s vision. These hemangiomas should be seen by a vascular anomalies specialist and a pediatric ophthalmologist (eye doctor) on a regular basis.

Psychological effect

Hemangiomas that cause disfigurement or functional limitations may affect the quality of life of both the children and their families due to the fact that the majority of hemangiomas occur in visible locations on the head and neck and they can distort anatomical landmarks. Disfigurement can cause devastating psychological effects for parents and children. The negative reaction from strangers, social stigmatization, sadness, stress and low self-esteem are some of the common reported effects of having such lesions.

Symptoms of Hemangioma

Hemangiomas can take on a different appearance depending on the location of the birthmark.

Strawberry hemangioma

Infantile hemangiomas will typically grow and change appearance during the first 6 to 12 months of life. At birth, your child may have a faint red or pink mark, but these birthmarks generally become larger and more noticeable during the first year. They can also become raised lumps. After that first year, they generally shrink over the next several years.

Hemangioma complications

These complications can occur from a hemangioma:

Diagnosis and test

Clinical exam: Hemangiomas differ in appearance depending upon how deep they develop in the skin. Hemangiomas on the surface of the skin (superficial hemangiomas) are commonly bright red and raised. Often they will first appear as a flat, red area. Deeper hemangiomas tend to be skin-colored or slightly bluish with a smooth surface. Often, hemangiomas will have both superficial and deep parts (combined or mixed hemangioma).

Imaging: Imaging is not usually necessary except under special circumstances. If your child has a hemangioma of the middle-lower back, see your doctor to decide whether imaging of the spine (special pictures, most commonly MRI) may be appropriate. If your child has multiple (more than 5) hemangiomas, it is recommended your child be seen by a doctor to determine whether an ultrasound of the liver or other evaluation is appropriate.

Pathology: Hemangiomas are most often diagnosed by physical examination and so rarely require a skin biopsy (when a small piece of skin is taken for examination under the microscope).

Genetics (if applicable): There is no known gene that causes hemangiomas and thus genetic testing is unnecessary.

Treatment

Treatment is dependent upon both the stage of growth (proliferation vs. involution) of the lesion, the presence of complications and emotional needs and considerations. Observation, drug therapy, laser therapy, and surgical removal are the four most common management options. In some patients, a combination of several of these treatments may be used over time.

Observation: In most cases, observation is the best course to follow, especially when the hemangioma is involuting and your child’s functioning is not impaired.

Drug therapy: Medical therapy is used for complicated hemangiomas in the proliferative phase. Their purpose is to slow the growth and decrease the size of the lesion to prevent further complications. Medical therapy can be topical, injected, taken orally or given intravenously. Medications include:

Laser therapy: Laser therapy is used to treat ulcerated hemangiomas and superficial residual skin telangiectasias. This treatment option has not proven to be effective during the early growth phase of hemangiomas and can cause significant scarring.

Surgery: Surgery may be advised for selected patients, including (1) children with painful and ulcerated hemangiomas that do not heal; (2) children whose lesions interfere with breathing, vision, or other vital functions; (3) those who have hemangiomas that do not completely involute; and (4) those in whom hemangiomas have resulted in unacceptable scarring or deformity.

Wound care: Ulcerated hemangiomas may require aggressive wound care, treatment with topical antibiotics, laser therapy, and/or surgical removal.

Prevention

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