Cold Agglutinin Disease (CAD) – Types, Causes and Diagnosis

Overview Cold agglutinin disease is a form of autoimmune hemolytic anemia caused by cold-reacting autoantibodies (a type of protein produced by the immune system). Primary cold agglutinin disease is usually associated with monoclonal (produced from a single ancestral cell by repeated cellular replication) cold-reacting autoantibodies. Primary cold agglutinin disease is chronic …

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Neurocutaneous Syndromes – Symptoms and Causes

What are Neurocutaneous Syndromes? Neurocutaneous syndromes is the term used for a group of rare neurological disorders that affect the brain, spinal cord, organs, skin, bones and peripheral nerve. Present at birth (congenital), these disorders are chronic, lifelong conditions. Each disorder has different symptoms, and can include tumors, hearing loss, …

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Wells Syndrome or Eosinophilic Cellulitis – Overview and Causes

Definition Wells syndrome or Eosinophilic cellulitis is an acute, rare dermatosis of unknown etiology. Eosinophilic cellulitis is reported infrequently in children and is manifested by eosinophil infiltration in the dermis. Eosinophilic cellulitis presents with sudden onset of single or multiple mildly painful or pruritic, erythematous plaques. The lesions are usually …

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