HIV/AIDS – Causes, Risk factors, Treatment and Prevention.

Introduction

HIV is a virus that attacks the immune system, which is our body’s natural defense against illness. The virus destroys a type of white blood cell in the immune system called a T-helper cell, and makes copies of itself inside these cells. T-helper cells are also referred to as CD4 cells.

The virus is actually not one, but several different viruses in the class of Retroviridae and the genus Lentivirus. The species differs and there is a larger list of subtypes. There are two major types: HIV 1 and HIV 2 – HIV 1 is thought to originate from chimpanzees and gorillas in western Africa; HIV 2 originates from sooty mangabeys (another ape) found in Senegal and Ghana. HIV 1 is the more deadly and is the cause of the AIDS pandemic and can be divided into the M, N, O, and P subgroups, but HIV 2 is also known to cause AIDS.

Structure of HIV

As HIV destroys more CD4 cells and makes more copies of itself, it gradually breaks down a person’s immune system. This means someone living with HIV, who is not receiving treatment, will find it harder and harder to fight off infections and diseases. HIV spreads through bodily fluids that include:

  • Blood
  • Semen
  • Vaginal and rectal fluids
  • Breast milk

Replication process of HIV viruses in human body

  • The virus infects the body’s macrophages, dendritic cells, and T-cells, viz. most often the CD4+ lymphocytes, by attaching itself to them via its gp120 protein to the e.g.
  • T-cell’s CD4+ protein. The CCR-5 protein then induces the fusion of the membranes. An inherent property of lentiviruses is that they have a single-strand RNA strand, not DNA, and this strand is injected when the cytoplasm’s merge as the HIV’s membrane fuses with that of the T-cell.
  • The RNA is converted into DNA by reverse transcriptase and is inserted into the T-cell’s genome strand using DNA integrase. Hence, the virus is literally replacing part of the human body.
  • The infected T-cell now produces HIV RNA and amino acids that form new HIV viruses and their protein coats. These viruses then spread throughout the body the infection rate increases.
  • The T-cells then die, causing AIDS as the immunodeficiency occurs when the majority of T-cells are denatured. At the replication of the viral RNA, which happens 10 billion times per day, there is a chance of mutation of one nucleotide per 9 200 nucleotides, meaning resistance could develop.
  • The virus is then spread via blood transfusions, sexual intercourse, or during birth (i.e. mother-to-child transmission, MTCT).
  • Everyday activities such as sharing food and water, kissing, shaking hand, or using the same toilet are not factors that spread the condition.
  • AIDS occurs when the body catches a secondary, an opportunistic, disease due to the decreased immune defense strength.

Stages involved in HIV patient

HIV advances in stages, overwhelming your immune system and getting worse over time. The three stages of HIV infection are:

  1. Acute HIV infection

The first few weeks after infection is called the acute infection stage. During this time the virus rapidly reproduces. Your immune system responds by producing HIV antibodies. Many people experience temporary flu-like symptoms during this stage. Even without symptoms, HIV is highly contagious during this time. Some of the symptoms during this stages includes:

  • Fever (raised temperature)
  • Body rash
  • Sore throat
  • Swollen glands
  • Headache
  • Upset stomach
  • Joint aches and pains
  • Muscle pain.
  1. Clinical latency

After the first month or so, HIV enters the clinical latency stage. This stage can last from a few years to a few decades. Progression can be slowed with antiretroviral therapy. Some people have symptoms. Many people do not, but it’s still contagious. As the virus progresses, you’re left with fewer T cells. This makes you more susceptible to disease, infection, and infection-related cancers.

  1. AIDS (acquired immunodeficiency syndrome)

Without treatment, HIV is likely to advance to AIDS. At that point, the immune system is too weak to fight off life-threatening disease and infection. Untreated, life expectancy with AIDS is about three years.

AIDS is a disease caused by HIV. It’s the most advanced stage of HIV. But just because you have HIV doesn’t mean you’ll develop AIDS. HIV destroys T cells called CD4 cells. These cells help your immune system fight infections. Healthy adults generally have a CD4 count of 800 to 1,000 per cubic millimeter. If you have HIV and your CD4 count falls below 200 per cubic millimeter, you will be diagnosed with AIDS.

You can also be diagnosed with AIDS if you have HIV and develop an opportunistic infection that is rare in people who don’t have HIV. AIDS weakens your immune system to the point where it can no longer fight off most diseases and infections. That makes you vulnerable to a wide range of illnesses, including:

  • Pneumonia
  • Tuberculosis
  • Candidiasis
  • Cytomegalovirus, a type of herpes virus
  • Cryptococci meningitis
  • Toxoplasmosis, an infection causes by a parasite
  • Cryptosporidiosis, an infection caused by an intestinal parasite
  • Cancer, including Kaposi’s sarcoma (KS) and lymphoma
  • Kidney disease

Symptoms that you may have during this time can include:

  • Weight loss
  • Chronic diarrhea
  • Night sweats
  • A fever
  • A persistent cough
  • Mouth and skin problems
  • Regular infections
  • Serious illnesses or diseases

Historical view of HIV/AIDS

Researchers found the earliest case of HIV in a blood sample of a man from the Democratic Republic of Congo. It’s said that the virus spread from chimpanzees to humans sometime before 1931, most likely during “bush meat trading.” While hunting chimpanzees, hunters would come in contact with animal blood.

Before the 1980s, researchers estimate that about 100,000 to 300,000 people were infected with HIV. The earliest case was confirmed in 1968, in Robert Rayford, a 16-year-old teenager, who never left the Midwest or received a blood transfusion. This suggests that HIV and AIDS may have been present in the United States before 1966.

But before AIDS was identified, the disease appeared as other immunodeficiency conditions like Pneumocystic carinii pneumonia (PCP) and Kaposi sarcoma (KS). A year after scientists identified AIDS they discovered the cause: HIV.

Epidemiology in worldwide

Since the beginning of the epidemic, more than 70 million people have been infected with the HIV virus and about 35 million people have died of HIV. Globally, 36.7 million [30.8–42.9 million] people were living with HIV at the end of 2016. An estimated 0.8% [0.7-0.9%] of adults aged 15–49 years worldwide are living with HIV, although the burden of the epidemic continues to vary considerably between countries and regions. Sub-Saharan Africa remains most severely affected, with nearly 1 in every 25 adults (4.2%) living with HIV and accounting for nearly two-thirds of the people living with HIV worldwide.


Statistics on causes of HIV/AIDS

Causes or Possibilities of HIV/AIDS

Some of the ways HIV is spread from person to person include:

  • Having unprotected sex with an infected person. This is the most common route of transmission
  • Sharing needles, syringes, and other items for injection drug use with an infected person
  • Passing it on to an unborn child if the mother is HIV-positive
  • Passing it on to a baby through breast milk if the mother is HIV-positive
  • Being exposed to infected fluids, usually through needle sticks.
  • Having a blood transfusion or organ and tissue transplant can also transmit the virus. But rigorous testing for HIV in blood ensures that this is very rare in the United States.

It’s theoretically possible, but considered extremely rare, for HIV to spread via:

  • Oral sex
  • Being bitten by an infected person
  • Contact between broken skin, wounds, or mucous membranes and HIV-infected blood or fluids

HIV does NOT spread through:

  • Skin-to-skin contact
  • Hugging, shaking hands, or kissing
  • Air or water
  • Eating or drinking items, including drinking fountains
  • Saliva, tears, or sweat (unless mixed with blood from an infected person)
  • Sharing a toilet, towels, or bedding
  • Mosquitoes or other insects

Complications during HIV

  • Tuberculosis
  • Hepatitis
  • Toxoplasmosis
  • Sexually transmitted infections
  • Liver or kidney damage
  • Urinary tract infection

Testing and Screening of HIV (Diagnosis)

There are four main types of HIV test:

  • Antibody Screening Tests: These tests check for a kind of protein that your body makes in response to the HIV infection, 2-8 weeks later. They’re also called immunoassay or ELISA tests.
  • Antibody/Antigen Combination Tests: The CDC recommends these blood tests. They can detect HIV as soon as 20 days earlier than antibody screening tests. They check for HIV antigen, a protein called p24 that’s part of the virus that shows up 2-4 weeks after infection, as well as HIV antibodies. A rapid antibody/antigen test can give you results in 20 minutes.
  • RNA Test: This looks for the virus itself and can diagnose HIV about 10 days after you’ve been exposed. It’s expensive, though, so it’s usually not the first test. But if you’re at high risk and you have flu-like symptoms, your doctor may want to use it.
  • In-Home Test Kits: Two kits are available. One option is to prick your finger to get a small blood sample that you send to a lab. For the other, you’ll swab your upper and lower gums and test the sample in a vial. You get a result in 20 minutes.
  • Western blot or indirect immunofluorescence assay
  • HIV-1 nucleic acid test, which looks for the virus itself

Treating of HIV/AIDS

The classes of anti-HIV drugs include:

  • Non-nucleoside reverse transcriptase inhibitors (NNRTIs). NNRTIs disable a protein needed by HIV to make copies of itself. Examples include efavirenz (Sustiva), etravirine (Intelence) and nevirapine (Viramune).
  • Nucleoside or nucleotide reverse transcriptase inhibitors (NRTIs). NRTIs are faulty versions of building blocks that HIV needs to make copies of itself. Examples include Abacavir (Ziagen), and the combination drugs emtricitabine-tenofovir (Truvada), and lamivudine-zidovudine (Combivir).
  • Protease inhibitors (PIs). PIs disable protease, another protein that HIV needs to make copies of itself. Examples include atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva) and indinavir (Crixivan).
  • Entry or fusion inhibitors. These drugs block HIV’s entry into CD4 cells. Examples include enfuvirtide (Fuzeon) and maraviroc (Selzentry).
  • Integrase inhibitors. These drugs work by disabling integrase, a protein that HIV uses to insert its genetic material into CD4 cells. Examples include raltegravir (Isentress), elvitegravir (Vitekta) and dolutegravir (Tivicay).
  • Fusion Inhibitors: Fusion inhibitors are a new class of drugs that act against HIV by preventing the virus from fusing with the inside of a cell, preventing it from replicating. The group of drugs includes Enfuvirtide, also known as Fuzeon or T-20.
  • Antiretroviral therapy (ART) is the use of HIV medicines to treat HIV infection. People on ART take a combination of HIV medicines (called an HIV regimen) every day. ART is recommended for everyone infected with HIV. ART can’t cure HIV, but HIV medicines help people with HIV live longer, healthier lives. ART also reduces the risk of HIV transmission.

Prevention of HIV/AIDS

Because the most common ways HIV is transmitted is through anal or vaginal sex or sharing drug injection equipment with a person infected with HIV, it is important to take steps to reduce the risks associated with these. They include:

  • Know your HIV status. Everyone between the ages of 13 and 64 should be tested for HIV at least once. If you are at increased risk for HIV, you should be tested for HIV at least once a year.
  • If you have HIV, you can get medical care, treatment, and supportive services to help you stay healthy and reduce your ability to transmit the virus to others.
  • If you are pregnant and find that you have HIV, treatments are available to reduce the chance that your baby will have HIV.

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97 comments

  1. How can someone be infected with HIV /Aid through blood?

    • One can infected with HIV through blood via HIV infected blood transfusion.
      If needles used in HIV patients is reused in healthy individual.

  2. Am a biochemist, I did a research on HIV in the year 2013, “bee stings: possible cure for HIV”. In this write up I feel the need that it be modified… with regards to the research work in quote! most likely in the area of cure and preventives. Thank you.

  3. If you’re HIS positive is it true that you can stay more than ten years without taking arv? is there cure of Aids as research studies has shown?

    • As you said, research studies are still going on to cure AIDS, but there are medications and treatments to overcome the excruciating pain and symptoms temporarily. This temporary medications and treatments leads the Aids Patient to extent their life for 10 or more than 10 years.

  4. I’m HIV Negative,Can I Impregnate a HIV Positive Woman and Remain Negative?

    • It is important to remember that no matter how low the viral load of the partner living with HIV – even if it is undetectable – there is always some risk of passing HIV to the uninfected partner with any type of unprotected sex. If you intend to have unprotected sex, it is important to tell your sexual partner that you are living with HIV.

      The HIV-negative male can now consider using Viread (tenofovir) or Truvada (tenofovir/emtricitabine) as Pre-Exposure Prophylaxis, or PrEP. PrEP involves taking HIV drugs before being exposed to HIV to prevent himself from becoming infected. While having an undetectable viral load can greatly reduce your chances of spreading HIV to your partner, it does not provide 100 percent protection.

      There are several methods to impregnate a women with HIV+ve. Please consult with your Doctor before planing for a baby.

  5. Is Itching in head ,Face,arms without rushes associated with HIV and AIDS?

    • It might be due to other diseases symptoms. Don’t decide by yourself unless you consult with a specialist. Please consult any dermatologist regarding your problem.

  6. please is their no cure for HIV or is the research still on process

    • There is no cure for HIV and AIDS yet. However, treatment can control HIV and enable people to live a long and healthy life.
      Research is still going on.

  7. good I love this

  8. BENONG-IKONG WILBERT

    pls how long can people live with HIV when on medication/treatment.

  9. 2007 l test for HIV negative, 2017 l so test negative. l sleep we a girl 2012, 2017 the girl die with AIDS and that 2017 l test negative?

  10. please what are the drugs to be taken when someone is been infected? thanks

  11. how can get HIV through fluid?

  12. how do u known that u have AIDS

  13. This application is very educative. Thanks for the good job
    Can a negative husband use anti retroviral drug to help himself. Which other measures can he take to remain negative

    • At some extent protected sex may also lead to HIV positive. It is advised to get help from a doctor whether to have ARV (Anti retro viral) when a person remains HIV negative.

  14. sir, why are homosexuals/male to male sexual contact more prone to have HIV?

    • The fact that HIV prevalence among men who have sex with men is so high in many countries means that members of this group have an increased chance of being exposed to the virus, due to mainly having sex within this group.

  15. Can HIV positive husband who is on treatment pass it on to his wife who is HIV negative without unprotected sex?

  16. Please what is the meaning of HIV 240.

  17. I had unprotected sex four months ago. I tested hiv negative at 3months and 4months but I have muscle aches, joint pains, stomach upset,neck pain and sometimes headache. please what could be the possible cause. I’m confused.

  18. How many days can you test for HIV if you sex with a positive person?

    • One recommended strategy is to get tested 2-4 weeks, 3 months, and 6 months after a risky exposure. Using a senstitive antigen/antibody HIV test, of those who are infected, most will test positive at 1 month; almost all will test positive at 3 months; and the rest will test positive at 6 months.

  19. I am HIV positive but my blood is clotting what is the cause

  20. what’s the time limit for prophylaxis to work after exposure

    • Post-exposure prophylaxis (PEP) involves taking antiretroviral (ARV) medicines very soon after a possible exposure to HIV to prevent becoming infected with HIV. PEP should be started as soon as possible to be effective and always within 72 hours (3 days) after a possible exposure to HIV.

  21. please, I want to know the curative medicine of HIV/AIDS.

  22. have dated a guy for four years now but just last week he was tested positive and am nagative i love this guy pls what should I do?

  23. you can as well contact a herbalist doctor for help

  24. how can a person be affected with HIV through semen?

  25. can an anopheles mosquito pass AIDS from an infected person to another through the blood?

  26. with HIV viral load test result what is the meaning.Target not Detected

  27. support us superbbbb

  28. Tollaba M. Gideon

    I have lean alot please someone should u
    help me
    cos my partner is reactive

  29. Yes, definitely there are stages in AIDS.

  30. Is it true that circumcised men and women can be safe of hiv infection

  31. Can one be infected with HIV virus through kissing an infected person?

  32. What is the sign and symptoms that someone has been suffering from HIV is it any type of HINTS ??

  33. Can HIV be the cause of hypertension

  34. if u eat food mixed with blood of an infected person, can u get infected?

    • According to the World Health Organization (WHO), HIV cannot be transmitted by water or food. In fact, HIV does not live long outside the human body. Even if the food contained small amounts of HIV-infected blood or semen, exposure to the air, heat from cooking, and stomach acid would destroy the virus.

  35. please i want to know, when you have HIV is there any drug that can prevent you from getting AIDS. Or do you have any means to convect to negative without extending to AIDS.

  36. Can HIV/AIDS end?

  37. Your Name Peter Karani

    which food can been taken by the person who is HIV &ADS ?

    • Eating a diet high in vegetables, fruits, whole grains, and legumes
      Choosing lean, low-fat sources of protein
      Limiting sweets, soft drinks, and foods with added sugar
      Including proteins, carbohydrates, and a little good fat in all meals and snacks

  38. and they gave me medication to be given to my baby when my baby is 1year then I stop breastfeeding and I stop the medication given too pls what does it means.

  39. hiv is abbreviation for….

  40. can you have sex with HIV positive using condom

  41. can a genital wart illness leads to hiv positive?

  42. can HIV positive gives birth?

    • Yes, they can. Although HIV can pass from a woman with HIV to her child during pregnancy, at the time of birth, or when breast-feeding the infant, medical treatment of both the mother and her infant can minimize the chances of that happening. HIV infection in both the mother and the biologic father does not appear to affect the likelihood of having an HIV-infected baby. Women living with HIV ideally should start antiretroviral therapy (ART) before pregnancy, both for their own health and to reduce the risk of HIV transmission during pregnancy.

  43. why is HIV positive not allow to work in hotel especially as waiter or waitress.

  44. please What type of sexual intercouse cause HIV? is it the one with weak eraction from the man or one with hard erection? I mean hard sex?

  45. can a discordant person get infected HIV

  46. How many years can you liv been positive when you are just 26 now.and u are on drugs .and can u still marry and have nagetive child

    • The average life expectancy for a 20-year-old who remains HIV negative, at least in industrialized nations, is an additional 60 years—with death occurring, on average, at the age of 80.

  47. Your Name. Naomi

    if someone have HIV for ten years and he did not know about it,please tell me what to do

  48. is their any way I can know that I got affected when I had both oral and varginal sex from a partner I don’t trust.

  49. how one can treat hiv

  50. Nigeria students are gradually working on the cure but we need support @thefountainschool. ph

  51. how can we cure HIV and AIDS what is the cause of all this disease is any many diseases that they create this disease if maybe it’s all these different diseases that cause HIV and AIDS then let’s take all the medicines of all different diseases then we mix them together and see what we can have different diseases that they cause HIV and AIDS maybe if maybe we mix all the medication we can cure all those different diseases that they made HIV and AIDS

  52. can alcohol intake,smoking prevent easy diagnose of HIV?

  53. Augusta M Bunduka

    This is good for us so HIV is real
    Thanks for your Advises

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